Computational Systems Biology: Modeling and Simulation of Biological Systems

Description: (Same as Bioengineering CM186, Computational and Systems Biology M186, and Ecology and Evolutionary Biology M178.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM286. Letter grading.

Units: 5.0
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