NEURO 240

Phenotypic Measurement of Complex Traits

Description: Lecture, three hours. Preparation: background in human genetics helpful. Integrative approach to understanding gene to behavior pathways by examination of levels of phenotype expression across systems (cell, brain, organism), across species (invertebrate, fly, mouse, human), and throughout development across varying environmental milieus. Using examples from human disorders such as schizophrenia and Alzheimer's disease, linking of these diverse approaches in genetic research to map out integrative system of understanding basis of complex human behavior. Emphasis on basic understanding of methods used at each level of phenotype analysis, along with major resources that can be accessed to gain insight to gene-behavioral links. Letter grading.

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