The amount of material covered in class is what makes the class kind of difficult. There are a lot of things to memorize for both parts of the lecture. I found Friscia's part easier than Phelps' part. The material covered in lecture for Friscia was the same material covered during lab. Whereas the material covered in lecture by Phelps was different than the material covered during lab. I definitely found Phelps' part harder due to the amount of detail she goes over on some topics. For the quizzes and midterm you should write everything you know about the topic/word. Make sure to understand the cranial nerves stuff very well.
I advice using your time during open labs wisely and attend every one of them. Ask your TA and UAs all the questions you have and ask them of tips about how they were able to understand and memorize all the material. There are some useful mnemonics that my TA and UAs gave us to memorize the material.
Both of the professors have office hours and Q&A sessions every week. Moreover, it is useful to attend the office hours of your TA because you can see what you got wrong on the quizzes, practicum, and midterm. Ask them about what specific details they were looking for each of the answers.
The course consisted of 1 midterm (300 pts.), final (300 pts.), 2 practicums (140 pts./each), and 6 quizzes (20 pts./each). There are some extra credit points offered on each of them. The class is not graded on a curve, the professors will emphasize this throughout the quarter.
The book is not really required for the class. It is useful because it has diagrams that will help you understand the material and you can refer to it if you do not understand anything in lecture. However, the book goes into more detail on some topics that what is covered in lectures. Both professors provide the notes/outline of the material for each lecture before class. Make sure to listen to the lectures again and catch anything you missed. Also, make sure to take a look at the animations and presentations of each lecture while you listen because the video is not recorded.

I am coming back from just finishing PhySci 111B... and I am very very happy I stayed a PhySci major despite all the negative things Ive heard. YES, it is hard. YES, I did question my abilities like crazy. But I and many other people did this! You can too. Dont let anyone tell you what you should or shouldnt do. If you want to be PhySci, BE PHYSCI!!! 107 was the best class Ive taken so far and I would do the series all over again if that meant choosing phy sci again. Good luck incoming juniors!